Heparin Anticoagulation

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Heparin and anticoagulation.

Heparin, a sulfated polysaccharide, has been used as a clinical anticoagulant for over 90 years. Newer anticoagulants, introduced for certain specialized applications, have not significantly displaced heparin and newer heparin-based anticoagulants in most medical procedures. This chapter, while reviewing anticoagulation and these newer anticoagulants, focuses on heparin-based anticoagulants, in...

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Heparin anticoagulation in acute brain ischemia.

Progressive neurological deterioration in patients with recent stroke or transient ischemic attack (TIA) is a distressing and all too common occurrence. Anticoagulation is an important therapeutic consideration for many of these patients. The use of heparin in patients with acute brain ischemia will be reviewed in this paper. Anticoagulation with heparin is often considered in the following cli...

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comparison of enoxaparin sodium and standard heparin for hemodialysis anticoagulation

methods this randomized, crossover study with parallel design was conducted in 45 patients who required maintenance hemodialysis due to end-stage renal failure. four patients with known bleeding disorders, receiving anticoagulant drugs and receiving drugs which could affect heparin activity were excluded. all patients were randomly assigned to receive either enoxaparin sodium (0.7 mg/kg) or sta...

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Rapid heparin anticoagulation: use of a weight-based nomogram.

The rapidity with which heparin anticoagulation is achieved is essential to a positive clinical outcome in patients with deep venous thrombosis or pulmonary embolus. However, adequate anticoagulation is frequently not achieved, either as a result of dosing regimens that do not take heparin kinetics into account or because of clinicians' wariness of possible hemorrhagic complications associated ...

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Argatroban anticoagulation in patients with heparin-induced thrombocytopenia.

BACKGROUND Heparin-induced thrombocytopenia (HIT) is an intensely prothrombotic syndrome managed by discontinuation of heparin therapy and substitution of an alternative inhibitor of thrombin. We describe our experience with argatroban, a direct thrombin inhibitor, in patients with HIT or HIT with thrombosis (HITTS). METHODS In this multicenter, nonrandomized prospective study, 418 patients w...

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ژورنال

عنوان ژورنال: Clinical Cardiology

سال: 2007

ISSN: 0160-9289,1932-8737

DOI: 10.1002/clc.20108